2019.03.24
Deciphering the Levels of Containment for Non-Sterile Compounds
Does your pharmacy require Level A, B, or C containment?
- The first step to evaluate the required level of containment is to reference the NIOSH Hazardous Drugs List and review the Safety Data Sheets for the Active Pharmaceutical Ingredient(s) (APIs) with which you compound.
- Once you have determined which of your APIs are hazardous (NIOSH and/or WHMIS hazards), a risk assessment must be undertaken to identify the appropriate level of containment to minimize contamination of each compounded product and to provide adequate protection for personnel.
- Please note: Hazardous drugs which are classified by NIOSH as Group 1 require Level C containment and are not eligible for an assessment of risk.
Important: In Alberta, where there is uncertainty as to the level of risk, the higher standard must be adhered to.
Level A
|
Separate space designated for compounding | |
Level B
|
Separate well-ventilated room Larger workspace and appropriate equipment Environment conducive to little or no interruptions May require a ventilated containment device when certain powders, aromatic products or hazardous products are compounded |
|
Level C
|
Separate room Well-ventilated with appropriate air exchange, negative pressure Appropriate containment device (C-PEC) for materials being compounded |
References:
Standards for Pharmacy Compounding of Non-Sterile Preparations
https://abpharmacy.ca/sites/default/files/Standard_Pharmacy_Non-sterile_Compounding.pdf
Guidance Document for Pharmacy Compounding of Non-sterile Preparations
https://abpharmacy.ca/sites/default/files/Guidance_Pharmacy_Non-sterile_Compounding.pdf
